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New Citations in March 2026
2026-04-13 295

New Citations in March 2026

In March 2026, AntibodySystem products continued to empower cutting-edge multidisciplinary research worldwide. Related findings were published in journals such as Nature Sensors, Phytomedicine, Alzheimer’s Research & Therapy, Virology, and ACS Nano. These studies span critical fields including early cancer diagnostics, bone metabolic diseases, renal fibrosis, neuroimaging, viral vaccines, and tumor immunotherapy, continuously driving innovation at the frontier of science and clinical translation.

Let’s explore some representative publications citing AntibodySystem products in March 2026.

IF 16 ACS Nano

Title: Nanodiamond-Mediated Targeted Delivery of Nanobodies and Immunostimulatory RNA for Breast Cancer Therapy

Core Finding: This study developed a nanodiamond–nanobody–immunostimulatory RNA ternary delivery system. Using the EGFR-specific nanobody 7D12, the system achieves precise targeting of breast cancer cells while co-delivering immunostimulatory RNA to activate innate immunity. This synergistic strategy effectively enhances tumor cell killing and suppresses tumor growth, providing a novel delivery platform for targeted immunotherapy in breast cancer.

Cited Product: RHB86908|Anti-Human EGFR/ERBB1/HER1 Nanobody (7D12)

Application: This EGFR-specific nanobody was used to functionalize nanodiamond carriers, enabling targeted recognition and precise delivery to breast cancer cells. It validated the tumor-targeting capability of nanobody-mediated delivery and established the core targeting component of the ternary therapeutic system.

Nature Sensors

Title: Oriented nanobody–field-effect transistor interfaces enable ultrasensitive cancer biomarker detection

Core Finding: This study developed a SNAP-FET biosensing platform enabling site-specific anchoring of nanobodies. By integrating genetic code expansion and click chemistry, nanobodies were immobilized in a precisely oriented manner, overcoming Debye screening limitations in serum. The platform achieved attomolar-level detection sensitivity for endometrial cancer biomarkers HE4 and CA125. A portable diagnostic device, ENDOCARE, was also developed, enabling rapid detection within 20 minutes with high consistency to ELISA results and strong diagnostic performance (AUC 0.843 for HE4, 0.813 for CA125).

Cited Products:

EHJ31001|Recombinant Human MUC16/CA125 Protein, C-His

MVV05491|Anti-Bacteriophage M13 Capsid Protein G8P Monoclonal Antibody (1A191), HRP

Application: The recombinant CA125 protein was used as an antigen for nanobody phage display screening, affinity validation, and sensor calibration. The HRP-conjugated antibody was used in monoclonal phage ELISA identification to ensure accurate screening of CA125-specific nanobodies.

IF 8.3 Phytomedicine

Title: A novel METTL3 inhibitor Nimbolide ameliorates osteoporosis via orchestrating osteoclastogenesis in an m6A-dependent manner

Core Finding: This study demonstrated that METTL3 is significantly upregulated in osteoporosis and promotes osteoclast overactivation via m6A modification of LRP1 mRNA. Nimbolide, a natural compound, was identified as a specific METTL3 inhibitor that directly binds METTL3 and suppresses its methyltransferase activity. This restores LRP1 expression, inhibits osteoclastogenesis, and alleviates osteoporosis in ovariectomized mice without significant toxicity.

Cited Product: YMJ15401|Recombinant Mouse METTL3 Protein, N-His

Application: This recombinant protein was used in molecular docking, molecular dynamics simulation, CETSA, and SPR assays to confirm high-affinity binding between Nimbolide and METTL3, establishing its mechanism as a METTL3 inhibitor.

 

IF 8.3 Phytomedicine

Title: Asiaticoside Attenuates Renal Fibrosis by Targeting STAT3 to Restore Th17/Treg Homeostasis

Core Finding: This study identified STAT3 as a key regulator of Th17/Treg imbalance in renal fibrosis. Asiaticoside directly binds to the STAT3 SH2 domain and induces its degradation through an allosteric “binding–destabilization” mechanism. This inhibits STAT3 activation and phosphorylation, reduces pro-inflammatory IL-17A, increases anti-inflammatory IL-10, restores immune balance, and significantly alleviates renal fibrosis and dysfunction.

Cited Products:

EME27701|Recombinant Mouse STAT3 Protein, C-His

EHE27701|Recombinant Human STAT3 Protein, C-His

Application: These recombinant proteins were used in SPR, molecular docking, and molecular dynamics simulations to validate cross-species binding and identify the SH2 domain binding site of Asiaticoside.

 

IF 7.6 Alzheimer’s Research & Therapy

Title: In-vitro interaction studies between the amyloid PET tracer florbetaben and the amyloid-beta targeting antibodies lecanemab and donanemab on AD brain samples reveal no interferences

Core Finding: This study demonstrated that the PET tracer florbetaben binds to different sites than therapeutic antibodies lecanemab and donanemab on Aβ plaques. No competitive binding or signal interference was observed, confirming that florbetaben PET can reliably monitor Aβ burden during antibody therapy.

Cited Product: VHC12501|InVivoMAb Anti-Human APP/Amyloid Beta Antibody (mAb158)

Application: This antibody was used in competitive immunohistochemistry to validate antibody binding epitopes and confirm lack of interference with PET tracer binding.

 

IF 2.4 Virology

Title: Potent protective ability of vaccinia virus LC16 strains lacking the B5R gene

Core Finding: This study engineered a B5R-deficient vaccinia virus strain, demonstrating reduced virulence while retaining strong humoral and cellular immune activation. The strain showed robust protective efficacy in animal models, providing a promising direction for safer vaccine development.

Cited Product: RVV13902|Anti-Vaccinia Virus (VACV) L1R Protein Antibody (M12B9)

Application: This antibody was used in Western blotting, immunodetection, and viral strain identification to validate protein expression and confirm recombinant virus characterization.

 

 

The above highlights represent selected publications citing AntibodySystem products in March 2026. AntibodySystem provides a comprehensive portfolio of research reagents, including recombinant proteins, flow cytometry antibodies, anti-IgE antibodies, phospho-specific antibodies, and ELISA kits, supporting applications in drug target discovery, immunoassays, allergy research, and cancer therapy development.

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